Research
Research into the causes and development of bronchiectasis, as well as its diagnosis and treatment, is the focus of current research.
Research activities
Based on the data from the PROGNOSIS Registry and the biobank, the establishment of further basic research-oriented and translational projects is already underway and continues to be planned.
Through intensified research activities, the topic of NCFB is expected to play an increasingly prominent role at national and international congresses.
Prof. Dr. Tobias Welte and Prof. Dr. Felix Ringshausen, both from Hannover Medical School, contributed as German representatives to the development of the European guideline “European Respiratory Society clinical practice guideline for the management of adult bronchiectasis” as part of the ERS Task Force.
A consensus-based German-language, trinational guideline (AT-CH-DE) on the management of adult patients with bronchiectasis was also developed under the leadership of the German Respiratory Society (Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin e.V., DGP; guideline coordination and scientific leadership: Prof. Dr. Felix Ringshausen, Hannover Medical School).
Publications in German
Raidt, J., Brillault, J., Brinkmann, F., Jung, A., Koerner-Rettberg, C., Koitschev, A., Linz-Keul, H., Nüßlein, T., Ringshausen, F. C., Röhmel, J., Rosewich, M., Werner, C. and Omran, H.
Pneumologie (Nov 2020)
Lommatzsch, M., Rabe, K. F., Taube, C., Joest, M., Kreuter, M., Wirtz, H., Blum, T. G., Kolditz, M., Geerdes-Fenge, H., Otto-Knapp, R., Häcker, B., Schaberg, T., Ringshausen, F. C., Vogelmeier, C. F., Reinmuth, N., Reck, M., Gottlieb, J., Konstantinides, S., Meyer, F. J., Worth, H., Windisch, W., Welte, T. and Bauer, T.
Pneumologie (Nov 26 2020)
Schwarz, C., Schulte-Hubbert, B., Bend, J., Abele-Horn, M., Baumann, I., Bremer, W., Brunsmann, F., Dieninghoff, D., Eickmeier, O., Ellemunter, H., Fischer, R., Grosse-Onnebrink, J., Hammermann, J., Hebestreit, H., Hogardt, M., Hugel, C., Hug, M., Illing, S., Jung, A., Kahl, B., Koitschev, A., Mahlberg, R., Mainz, J. G., Mattner, F., Mehl, A., Moller, A., Muche-Borowski, C., Nusslein, T., Puderbach, M., Renner, S., Rietschel, E., Ringshausen, F. C., Schmidt, S., Sedlacek, L., Sitter, H., Smaczny, C., Tummler, B., Vonberg, R., Wielputz, M. O., Wilkens, H., Wollschlager, B., Zerlik, J., Duesberg, U. and van Koningsbruggen-Rietschel, S.
Pneumologie (May 2018)
Rademacher, J., Buck, A., Schwerk, N., Price, M., Fuge, J., Welte, T. and Ringshausen, F. C.
Pneumologie (Aug 2017)
Ringshausen FC, Rademacher J.
Internist (Berl). 2016;57(2):142-52
Rademacher J, Ringshausen FC.
COPD in Deutschland. 2015 Aug; 50-52
Rademacher J, de Roux A, Ringshausen FC.
Pneumologie. 2015 Jul;69(7):391-3
Rademacher J, Schweigert M.
Zentralbl Chir. 2015 Feb;140(1):113-26; quiz 127-8
Ringshausen FC, Rademacher J, Welte T.
Dtsch Med Wochenschr. 2014 Apr;139(14):707-10
Rademacher J, Ringshausen FC.
Pneumologie. 2013 Jan; 67(1):40-7; 48-9
Rademacher J, Welte T.
Dtsch Arztebl Int. 2011 Dec;108(48):809-15
Ringshausen FC, Welte T.
Der Pneumologe. 2014/4
Rademacher J, Ringshausen FC.
Pneumologe. 2014/4
Dr. N. Derichs.
Pneumologe. 2014/4
Brückner U.
Pneumologe. 2014/4
Glöckl R, Kenn K.
Pneumologe. 2014/4
Flick H, Meilinger M, Wagner M, Olschewski H, Eber E.
Pneumologe. 2014/4
de Roux A.
Pneumologe. 2014/4
Publications in English
On the website of the European Bronchiectasis Registry EMBARC, you will find a selection of current publications in English:
SelectionRecent studies
To date, only a few controlled studies have been conducted, meaning that it is difficult to provide evidence-based recommendations for non-CF bronchoscopies.
The efficacy of many different substances is currently being investigated. A hypertonic saline solution is frequently used in clinical practice, as it has been shown to be beneficial in CF, although this has not yet been proven for non-CF bronchiectasis.
Following positive results from Phase II trials, inhaled mannitol is now in Phase III clinical trials.
Inhaled antibiotics may be of particular significance in patients colonised with Gram-negative pathogens. Tobramycin and colistin are established – albeit not approved – whilst aztreonam, ciprofloxacin and gentamicin are being tested in clinical trials. According to the results of several studies – albeit with only small sample sizes – macrolides appear to have an additional beneficial effect. Long-term therapy with inhaled antibiotics and/or macrolides is only indicated if a clearly positive effect is observed within three months of starting treatment (reduction in sputum volume, freedom from exacerbations).
ERADICATE STUDYFor doctors
Care for patients with frequent exacerbations (German)
An interview with Dr Felix C. Ringshausen and Prof. Tobias Welte